You can ReWire Reason into Protools, it can get taxing on the system though. As long as you look up some of the routing threads on here you should be able to use the 11r with no issues as an interface for any DAW.

Ever since Protools dropped the 11r as a plugin it hasn't been nearly as convenient, at least not enough to force me to use Protools over Logic Pro X (which also has similar breadth of synths and VI that reason has, though I still have both). You just have to set your routing to track the Direct and Amp sounds from the interface.

Are you on windows or a mac? What version?