Agreed. I shut it ALL down when I leave the studio. I have very good power conditioners, surge protection and UPS systems, but still I shut em all down when I turn off the lights.

I am a one man shop so if I ain't in there, it ain't being used. Sometimes things are off for 24 hours, and that does save a lot of wear and tear.

With the audio infaces, once you sever the communication link, whether you put your 'puter to sleep or shut off the interface, you'll have to re-establish it, reboot style. I have seen utilities for win that will reinitialize but from the reports they work sort of iffy. I haven't seen anything like it for OSX.

Just my $ .02