You won't be missing anything by working in Logic, except the input and output names, you have to know what input numbers (like Input 1, Input 2, etc.) correspond to the 11r counterpart (like Guitar Input, Mic Input, Rig output L, etc.). I made a post about the input-output assignments about a month or two back that should apply to your case. Other than that it is like any other interface, just make sure you download all the current Mac drivers and the standalone Eleven Rack Editor to be able to save, load, and adjust presets.