i think blending IR's is the answer to most problems we guitarist have. when i had the axe-fx II i discovered using two different cabs for a stereo effect. but better than the stereo effect is the feel i got. your ears never hear the exact same signal in each ear when you play with an amp in the room because the sound bounces off the walls before it hits your ears, and each ear hears something slightly different....and that makes it sound good.

blending 2 or more IR's into a stereo panned final cab is what i like.

another option i hear about is loading a bunch of IR's and mixing them to get one final mono IR. i like the idea, but i prefer a stereo output...even if i end up panning the stereo track in the final mix.