hmmmm, everything you hear depends on a lot of factors. the speakers you use play a big part, but also your ears. if you start off with a warm tone, then everything else sounds fizzy. if you start with fizzy, everything else sounds dark and muffled.

here's what i do:

first i listen to the sound of my amp in the room.

then i select an IR that sounds just as warm.

i may just jam on that for awhile.

if i want to get it sounding cd quality, i will listen to a cd of a guitar tone that i like and either change the IR or eq it to sound closer to the cd.