I just re-routed things with a hub and extension cable, and gave myself nightmares - 11R editor worked, but both Reaper and ProTools11 on my 2014 MBP got super flaky. Swapped out the USB hub I'd put in and all's well (still using a hub, just a different one).

And I have no problems shutting down and reconnecting my 11R without a reboot. No reason I'd leave it on 24/7, but I'm just a casual home user.
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"Say goodbye to all this, and hello to oblivion."