Midrange, yes my preference is based on keeping the signal digital so it is not converted and converted again (assuming the interface has the digital in). With regard to the USB, yes that is a digital signal too. As far as XLR vs TRS personally I have found the XLR to be better. I used the TRS into my Peavey classic 60/60 power amp and it never sounded as loud as I thought it should be. So as an experiment I tried it with the XLR and oh my god!! The volume almost plastered me on the opposite wall!!! So I have been using the XLR since and I think I have a better tone from them as well.
noguud: thank you, I am a PowerPoint wizard !! LOL!
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I'm a practicing guitarist, one day I hope to get it right..