Using Plugins

Is it possible to use the 11R as an interface and run DAW plugins? I can't seem to figure out how to get the dry signal muted. I'm using reaper.

It is definitely possible, but we need more info on 1.) your signal chain (connections into and out of your computer), and 2.) what you would like to happen versus what is currently happening..

I was able to figure out how to do this. If you run a patch cable from your loop send to the line input and set the mix at 100% and the return level at 0% you can use the 11R as an interface!