have you gone though and made sure all volume levels are up? are you getting signals on the meters? no sound from any/all outputs?
sometimes i opt to leave my fx loop gadgets at home...the presets ive made that have the fx loop enabled are then muted until i disable the loop. do you have any brain farts like that happening?
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MIM Fender Strat, Epi LP Std Plus, Epi WildKat, '79 Martin HD28, Vox AC15c1, Eleven Rack w/ERXP, G Major, GCP, Line6 M5, Mission EP-11